Could Port Wenn have a plague problem? That’s the huge question on Fox’s Best Medicine episode 11. “Mind Your Own Buboes” airs on Tuesday, March 24, 2026 at 8pm ET/PT.
“Mind Your Own Buboes” Plot: Port Wenn goes on lockdown when a patient with fleas sparks fears of a plague outbreak and Martin must deal with the town gossip when it revolves around him and Louisa. Also, Aunt Sarah feels betrayed by Greg and George and Louisa has an epiphany.
Season one stars Josh Charles as Dr. Martin Best, Abigail Spencer (Suits) as Louisa Gavin, Annie Potts (Young Sheldon) as Aunt Sarah, Josh Segarra (Sirens) as Sheriff Mark Mylow, and Cree (Twinless) as Elaine Denton. Recurring guest stars include Didi Conn as councilwoman Geneva Potter, Clea Lewis as pharmacist Sally Mylow, Stephen Spinella as Greg Garrison, Jason Veasey as George Brady, Cindy De La Cruz as Jeannie, John DiMaggio as Bert Large, Carter Shimp as Al Large, and Wattson as Copernicus.
Best Medicine Description, Courtesy of Fox:
The series follows Martin Best (Charles), a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child. Unfortunately, Martin’s blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, including schoolteacher Louisa Gavin (Spencer). He quickly alienates the town, even though he’s all they have.
Although Martin can expertly address any medical ailment or mystery in this idiosyncratic town, he’s really just desperate to be left the hell alone. Instead, he keeps getting dragged smack into the middle of their personal chaos, feuds, and fantasies. What the locals don’t know is that Martin’s terse demeanor masks a debilitating new phobia and deep-seated psychological issues that prevent him from experiencing true intimacy with anyone. But tenacity is the creed of everyone in their small village, and the people who live there may be exactly what the doctor ordered.
- Episode 2 “Bean There Done That” Preview
- Episode 3 “Take Me Out of the Ballgame” Preview
- Episode 4 “All the World’s Ablaze” Preview
- Episode 5 “Hello Darkness My Port Wenn” Preview
- Episode 6 “Eyewitness Blues” Preview
- Episode 7 “There Might Be Blood” Preview
- Episode 8 “The Bogfather” Preview
- Episode 9 “Doc Martin” Preview
- Episode 10 “Port Wenn-ings and a Funeral” Preview
- Episode 13 “Norway No How” Preview
This post was last modified on April 1, 2026 9:11 pm