‘Memory of a Killer’ Episode 1 Preview Starring Patrick Dempsey

Patrick Dempsey leads the cast of Fox’s new primetime drama Memory of a Killer. The psychological thriller, which premieres on January 25, 2026 at 10pm ET/PT, finds Dempsey playing a hitman with a secret. Part two of the series premiere will air on Monday, January 26 at 9pm ET/PT (its regular time slot).

In addition to Dempsey as Angelo Flannery, the season one cast includes Michael Imperioli as Dutch, Richard Harmon as Joe, Odeya Rush as Maria, Daniel David Stewart as Jeff, and Peter Gadiot as Dave. Aaron Zelman and Glenn Kessler serve as co-showrunners and executive producers.

Episode One Plot: “In the series opener, after carrying out a hit on his latest assigned target, Angelo begins to realize his mind may be failing him as his two, completely separate lives are slowly crashing together.”

Memory of a Killer Episode 1
Patrick Dempsey in ‘Memory of a Killer’ episode 1 (Photo by Jan Thijs © 2026 Fox Media LLC)

Memory of a Killer Synopsis, Courtesy of Fox:

Inspired by the book and 2003 award-winning Belgian film De Zaak Alzheimer, Memory of A Killer is a dramatic thriller starring Emmy nominee Patrick Dempsey as a hitman, Angelo Doyle, leading a dangerous double life while hiding an even deadlier personal secret.   Emmy winner Michael Imperioli stars opposite Dempsey in the role of Dutch, Angelo’s oldest friend and an accomplished chef whose restaurant is a front for criminal enterprise.

Michael Imperioli and Patrick Dempsey
Michael Imperioli and Patrick Dempsey in the special two-night premiere event (Photo by Jan Thijs © 2026 Fox Media LLC)
Daniel David Stewart and Odeya Rush
Daniel David Stewart and Odeya Rush in episode 1 (Photo by Jan Thijs © 2026 Fox Media LLC)
Patrick Dempsey
Patrick Dempsey in episode 1 (Photo by Jan Thijs © 2026 Fox Media LLC)
Patrick Dempsey and Michael Imperioli
Patrick Dempsey and Michael Imperioli in the series premiere (Photo by Jan Thijs © 2026 Fox Media LLC)