Discovery Channel’s trailer for the new season of Monsters Inside Me is squirm-inducing and gross, but also one of those things you just can’t look away from. The season, which is not for those with a weak stomach, premieres on November 11, 2026.
New episodes will air on Wednesdays at 10pm ET/PT on Discovery Channel.
Discovery Channel’s synopsis reads, “In the premiere episode, patients and their doctors unravel baffling illnesses and reveal an extraordinary medical first when a woman discovers live worms in her eye, prompting a search for answers about her health. Then, a hunter discovers that a tick bite has turned eating everyday food into a dangerous gamble, and a woman returns from Hawaii with parasites attacking her nervous system.
Throughout the season, these unseen threats disrupt ordinary lives, including a routine blood donation that exposes a woman’s hidden parasitic infection and a bout of searing pain that leads an Alaskan fishing guide to suspect a worm has traveled from his stomach to his liver. Medical mysteries continue to unfold as a newlywed facing brain surgery gets a shocking diagnosis, while a traveler fights an eye-destroying amoeba after an everyday habit puts her vision at risk.
Later, a reptile expert survives a crocodile encounter only to suffer organ failure, and a college athlete battles recurring illness as doctors search beyond a suspected Lyme diagnosis for answers.”
Nomadica Films produces the series for Discovery Channel.